The mood of people who respond best to Iris is generally low. They often feel restless and discouraged. Key symptoms related to the remedy are headaches and migraines accompanied by digestive disorders such as nausea, severe diarrhea, or cholera. Warning signals that precede a migraine include great exhaustion and blurring or loss of vision. Migraines are typically right-sided but may alternate from side to side. They usually center in the temple or around the eyes, and involve throbbing pain, severe nausea, vomiting, and profuse salivation. The head pain is typically aggravated by vomiting and is typically weekly. Native Americans used blue flag to treat stomach complaints, wounds and sores, colds, and earaches, and as a diuretic. Modern herbalists use the plant in detoxification treatments. The fresh root, dug up and chopped in summer, is steeped in alcohol.