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Simcor
Simvastatin + Niacin
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3.6
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RateADrug users have reported 8 Simcor side effects and 2 Simcor benefits.
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There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
Common Uses:
Simcor (niacin extended-release/simvastatin) is a prescription medication used for treating unhealthy triglyceride or cholesterol levels. It contains two different cholesterol medications - simvastatin (Zocor) and extended-release niacin (Niaspan).
Because of the effects of simvastatin and niacin, Simcor can help decrease the following "bad" forms of cholesterol and fats:
Total cholesterol
LDL cholesterol
Apo B cholesterol
Non-HDL cholesterol
Triglycerides.
Simcor also increases HDL cholesterol ("good" cholesterol)
Off Label Uses:
Using Simcor to prevent heart or blood vessel disease (cardiovascular disease), heart attacks, strokes, or other such problems would be considered to be off-label uses of Simcor.
Side Effects:
When taking Simcor, if you experience unexplained muscle pain, tenderness, or weakness (especially if accompanied by a fever or feeling of illness), it is important to contact your healthcare provider immediately.
Some of the most common side effects of Simcor include:
Flushing
Headache
Itching
Nausea
Back pain
Diarrhea
Some of the serious side effects of Simcor include:
There are several side effects that you should report immediately to your healthcare provider. These include, but are not limited to:
Muscle pain, tenderness, or weakness, especially if you also have a fever or feel ill, since these may be signs of serious breakdown of muscle, known as rhabdomyolysis.
Significant, unexplained changes in the amount of urine you produce (which may be a sign of kidney problems)
Signs of liver damage, such as:
Yellowing of the whites of the eyes or skin (jaundice)
Upper-right abdominal pain (stomach pain)
Dark urine
High liver enzymes (found using a blood test)
Signs of a stomach ulcer, such as:
Severe heartburn
Stomach pain
Loss of appetite
Dizziness
Vomiting blood
Blood in the stool (seen as dark-colored stools)
Easy bruising or bleeding (or bleeding that is slow to stop)
Gout
High blood sugar (hyperglycemia)
Signs of low blood pressure (hypotension), such as lightheadedness, dizziness, or fainting
An irregular heart rhythm (arrhythmia)
Signs of an allergic reaction, such as:
A rash
Itching
Joint pain
Anemia
Low white blood cell counts
Sensitivity to the sun
Fever and chills
Flushing
A general ill feeling
Hives
Wheezing or difficulty breathing
Swelling of the mouth, tongue, or throat.
Cautions / Warnings:
Some precautions and warnings to be aware of include:
Rhabdomyolysis (the severe breakdown of muscles) and other serious muscle problems have rarely been reported with Simcor and other statins. You are at greater risk for developing muscle problems, such as rhabdomyolysis, with Simcor if:
You have kidney damage
You are taking certain medications.
You drink grapefruit juice or use grapefruit products.
If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting Simcor. Alcohol can affect the way the liver works, indirectly affecting the Simcor.
Statins (such as simvastatin, one of the components of Simcor) have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting Simcor and several months after treatment has started. These tests may also be recommended if the Simcor dosage is changed.
Make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is with a fever or if you feel ill.
Simcor can increase blood sugar in people with diabetes. If you have diabetes, check with your healthcare provider before taking this medication.
Simcor can increase the level of uric acid in the blood, which can worsen (and possibly even cause) gout.
Simcor must be started at a low dose and increased gradually, in order to avoid intolerable flushing due to the niacin component (see Simcor Dosage and Niacin Flush for more information).
Simcor may increase the risk of bleeding, possibly due to decreased blood platelets.
Simcor is a pregnancy Category X medicine, meaning that it could potentially cause harm to your unborn child. The safety of Simcor in pregnant women has not been established. If you are pregnant and taking Simcor, talk to your healthcare provider immediately.
If you are nursing, it is not known whether Simcor passes through your milk. Therefore, if you are taking the drug, discuss with your healthcare provider whether to stop nursing or stop taking Simcor.
Drug Interactions:
Simcor (niacin extended-release/simvastatin) is a prescription cholesterol medication. Because it contains two different drugs, it has the potential to interact with quite a few other medications. Some of the medicines that may lead to drug interactions with Simcor include:
Amiodarone (Cordarone®, Pacerone®)
Bile acid sequestrant cholesterol medications, including:
Cholestyramine (Prevalite®, Questran®, Questran® Light)
Colesevelam (WelChol®)
Colestipol (Colestid®)
Blood pressure medications
Certain antibiotics, such as:
Erythromycin
Clarithromycin (Biaxin®)
Telithromycin (Ketek®)
Certain antifungals, such as:
Fluconazole (Diflucan®)
Itraconazole (Sporanox®)
Ketoconazole (Nizoral®)
Miconazole
Posaconazole (Noxafil®)
Voriconazole (VFEND®)
Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
Digoxin (Lanoxin®, Digitek®)
Danazol (Danocrine®)
Fibrates, such as:
Fenofibrate (Antara™, Lofibra™, Tricor®, Triglide™)
Gemfibrozil (Lopid®)
Grapefruit juice
Nefazodone (Serzone®)
Protease inhibitors, such as:
Amprenavir (Agenerase®)
Atazanavir (Reyataz®)
Darunavir (Prezista™)
Fosamprenavir (Lexiva®)
Indinavir (Crixivan®)
Lopinavir and ritonavir (Kaletra®)
Nelfinavir (Viracept®)
Ritonavir (Norvir®)
Saquinavir (Invirase®)
Tipranavir (Aptivus®)
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Cirrhosis of the liver
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Harth pain
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Liver Disorder
Lou Gehrig's Disease
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Lupus
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Male Enhancement
Mcardle's Disease
Medicine / Fluid Absorption
Meniere's disease
Meniere's Disease & Vertigo
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Menopause
Mental Health
Microscopic colitis
Migraine
Mild splenomegaly
Motion Sickness
Mouth & Gum Disorder
MRSA
Multiple Sclerosis (MS)
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Purple foods such as concord grapes, blueberries, plums, pomegranates, acai berries, red wine, and even eggplants are very high in antioxidants. Purple foods have been shown to protect your heart and vision, promote mental focus, and increase longevity. Research has indicated that purple foods may even be used to prevent or cure cancer.
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Simcor Comments
20 Jun 2012
I'm not sure the benefits are enough to justify the side effects.
—Posted by Anonymous
06 Oct 2011
Experienced moderate flushing during my first usage but it occured 12 hours after taking the pill. It was a scary experience because I thought any side effects would hit a lot sooner. Flushing occurred about 4 hours after taking a pill the second day; this time I noticed my knees and ankles turning red - flushing was limited to face, neck, arms the first day. Both times I took benadryl and the flushing ended in about an hour. Now, I stopped after the second dose because I noticed the back and sides of my thighs and claves (very muscular) looked as if the blood had been drained from them (pale white) with purple splotches. My doctor's nurse told me to continue taking but I refuse until I can speak directly with my doctor. No, this has nothing to do with status - the nurse has been great but I want to see the look on the doctor's face when I describe how I felt. A person's facial reaction can tell you a lot; I'm sure he's not going to prescribe something I don't need however there may be alternatives.
—Posted by Anonymous
28 Apr 2011
don't like it
—Posted by Anonymous
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20 Jun 2012
I'm not sure the benefits are enough to justify the side effects.
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06 Oct 2011
Experienced moderate flushing during my first usage but it occured 12 hours after taking the pill. It was a scary experience because I thought any side effects would hit a lot sooner. Flushing occurred about 4 hours after taking a pill the second day; this time I noticed my knees and ankles turning red - flushing was limited to face, neck, arms the first day. Both times I took benadryl and the flushing ended in about an hour. Now, I stopped after the second dose because I noticed the back and sides of my thighs and claves (very muscular) looked as if the blood had been drained from them (pale white) with purple splotches. My doctor's nurse told me to continue taking but I refuse until I can speak directly with my doctor. No, this has nothing to do with status - the nurse has been great but I want to see the look on the doctor's face when I describe how I felt. A person's facial reaction can tell you a lot; I'm sure he's not going to prescribe something I don't need however there may be alternatives.
—Posted by Anonymous
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28 Apr 2011
don't like it
—Posted by Anonymous
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12 Apr 2011
I have been on Simcor @1000mg/20mg for 1 year and my test results in the lab are meeting mine and Dr.'s goals set but I emphasize lab reports. I am curious if anyone has had any physical effects such as tingling and numbness of the fingers especially at nightime. I also have a servere pain in the "funny bone" area. Mine is very sensitive to touch and often is painful if I have to lift anything above 25 lbs. I am 64 and never have had these sensations until I believe I started with Simcor. I decided to stop the medication 2 weeks ago and I have noticed a large drop in the evening pain associated during the night. I have not been woken up once in these two weeks. I can only associate this drop to my dropping the medication. Has anyone had any similar results?
—Posted by Greg
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27 Apr 2011
I am experiencing muscle pain in the left knee joint. the pain feels more intense in the back of the calf. I am going to stop taking it to see if the pain subsides.
—Posted by Dann
07 Mar 2011
The constipation i have experienced since I started taking Simcor is the first in my life. I have always included plenty of fiber in my diet, drink alot of water, and excercise regularly. Now I am supplementing that with fiber capsules and a stool softener. I still experience constipation at least once a week (3 days without a bowel movement).
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