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Propylthiouracil
Propylthiouracil
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There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
Common Uses:
Propylthiouracil is indicated in the medical treatment of hyperthyroidism. Long-term therapy may lead to remission of the disease. Propylthiouracil may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy. Propylthiouracil is also used when thyroidectomy is contraindicated or not advisable.
Off Label Uses:
Currently there are no off label uses for Propylthiouracil.
Side Effects:
The most common side effects of Propylthiouracil are Abnormal skin sensations; change in taste; drowsiness; enlarged salivary glands; feeling of whirling motion; hair loss; headache; itching; muscle pain; nausea; skin color changes; stomach upset; swelling; swollen or painful lymph nodes.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood cell changes; fever; sore throat; unusual bleeding or bruising; vomiting; yellowing of the skin or eyes.
Cautions / Warnings:
Agranulocytosis is potentially the most serious side effect of Propylthiouracil therapy. Patients should be instructed to report any symptoms of agranulocytosis, such as fever or sore throat. Leukopenia, thrombocytopenia, and aplastic anemia (pancytopenia) may also occur. The drug should be discontinued in the presence of agranulocytosis, aplastic anemia (pancytopenia), ANCA-positive vasculitis, hepatitis, interstitial pneumonitis, fever or exfoliative dermatitis. The patient’s bone marrow function should be monitored.
Propylthiouracil can cause fetal harm when administered to a pregnant woman. Because the drug readily crosses placental membranes and can induce goiter and even cretinism in the developing fetus, it is important that a sufficient, but not excessive, dose be given. In many pregnant women, the thyroid dysfunction diminishes as the pregnancy proceeds; consequently, a reduction of dosage may be possible. In some instances, Propylthiouracil can be withdrawn 2 or 3 weeks before delivery.
If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be warned of the potential hazard to the fetus.
Postpartum patients receiving Propylthiouracil should not nurse their babies.
Rare reports exist of severe hepatic reactions including encephalopathy, fulminant hepatic necrosis and death in patients receiving Propylthiouracil. Symptoms suggestive of hepatic dysfunction (anorexia, pruritus, right upper quadrant pain, etc.) should prompt evaluation of liver function. Treatment with Propylthiouracil should be discontinued promptly in the event of clinically significant evidence of liver abnormality, including hepatic transaminases in excess of 3 times the upper limit of normal.
Drug Interactions:
Drug Interactions
Anticoagulants (Oral): The activity of anticoagulants may be potentiated by anti-vitamin-K activity attributed to Propylthiouracil.
β-Adrenergic Blocking Agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. A dose reduction of beta-adrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid.
Digitalis Glycosides: Serum digitalis levels may be increased when hyperthyroid patients on a stable digitalis glycoside regimen become euthyroid; a reduced dosage of digitalis glycosides may be required.
Theophylline: Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Laboratory animals treated with Propylthiouracil for > 1 year have demonstrated thyroid hyperplasia and carcinoma formation.1 Such animal findings are seen with continuous suppression of thyroid function by sufficient doses of a variety of antithyroid agents, as well as in dietary iodine deficiency, subtotal thyroidectomy, and implantation of autonomous thyrotropic hormone-secreting pituitary tumors. Pituitary adenomas have also been described.
This medication is not indicated for use in pregnant women. The drug appears in human milk and is contraindicated in nursing mothers.
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Purple foods such as concord grapes, blueberries, plums, pomegranates, acai berries, red wine, and even eggplants are very high in antioxidants. Purple foods have been shown to protect your heart and vision, promote mental focus, and increase longevity. Research has indicated that purple foods may even be used to prevent or cure cancer.
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Propylthiouracil Comments
01 Mar 2012
Things do get better, I have taken PTU for 6 months now, the bitter taste is just one of those things you get used to but I would rather have that than opt for surgery. You need to have a look at the Elaine Moore Q&A site which isdedicated to graves disease, a very informative website where you can also ask questions about this disease too. I had a lot less side effects from this than the carbimazole, dont get hung up on your TSH levels this might not budge until you are near remission you need to go off your FT4 levels, mine TSH increased when I went hypo due to the Propylthiouracil, you acn also get a lot of support from dailystrength website and join the graves disease group, we have a thyroid uk website but not many graves disease sufferers on there, if you need any more help keep in touch
—Posted by vicki
29 Feb 2012
Started taking meds PTU.. 3 times a day. Having some headaches, bitter taste in my mouth after taking pill. Have only been taking only for 1 week. Hopefully this helps my low 0.02 tsh. Any recommendations ? Please.. This is a terrible disease ... Feel horrible for anyone that has this!
—Posted by Julia
04 Feb 2012
I had itchy skin but this did disappear, as for the hair falling out mine is still doing this, I spoke to the consultant this week and he says its part of the condition not the tablets, its a hypo side effect so make sure your levels arent too low, mine are still low end of normal, there is only the MMI as your next option which I couldnt take , RAI or surgery and I would much rather take these tablets, good luck vicki :)
—Posted by vicki
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29 Feb 2012
Started taking meds PTU.. 3 times a day. Having some headaches, bitter taste in my mouth after taking pill. Have only been taking only for 1 week. Hopefully this helps my low 0.02 tsh. Any recommendations ? Please.. This is a terrible disease ... Feel horrible for anyone that has this!
—Posted by Julia
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01 Mar 2012
Things do get better, I have taken PTU for 6 months now, the bitter taste is just one of those things you get used to but I would rather have that than opt for surgery. You need to have a look at the Elaine Moore Q&A site which isdedicated to graves disease, a very informative website where you can also ask questions about this disease too. I had a lot less side effects from this than the carbimazole, dont get hung up on your TSH levels this might not budge until you are near remission you need to go off your FT4 levels, mine TSH increased when I went hypo due to the Propylthiouracil, you acn also get a lot of support from dailystrength website and join the graves disease group, we have a thyroid uk website but not many graves disease sufferers on there, if you need any more help keep in touch
—Posted by vicki
01 Feb 2012
Did not like this medicine! My hair thinned out terribly and the skin rash and headaches were not good either!
—Posted by Bee
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04 Feb 2012
I had itchy skin but this did disappear, as for the hair falling out mine is still doing this, I spoke to the consultant this week and he says its part of the condition not the tablets, its a hypo side effect so make sure your levels arent too low, mine are still low end of normal, there is only the MMI as your next option which I couldnt take , RAI or surgery and I would much rather take these tablets, good luck vicki :)
—Posted by vicki
01 Feb 2012
Did not like this medicine! My hair thinned out terribly and the skin rash and headaches were not good either!
—Posted by Anonymous
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01 Feb 2012
I hated taking PTU because it could not properly stabalize my thyroid levels, so the doctor kept increasing my dosages. I ended up taking 16 pills per day!
—Posted by Bee
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01 Feb 2012
I hated taking PTU because it could not properly stabalize my thyroid levels, so the doctor kept increasing my dosages. I ended up taking 16 pills per day!
—Posted by Bee
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