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Nplate
Romiplostim
,
Romisplostim
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There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
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Try adding more purple to your diet!
Purple foods such as concord grapes, blueberries, plums, pomegranates, acai berries, red wine, and even eggplants are very high in antioxidants. Purple foods have been shown to protect your heart and vision, promote mental focus, and increase longevity. Research has indicated that purple foods may even be used to prevent or cure cancer.
- Mark
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Nplate Comments
22 Feb 2017
Long term side effects? I am starting my 3rd yr, it scares me.
—Posted by sajones
30 May 2016
I experienced a slight tremor or muscle jerk in my right arm the next evening after receiving Nplate injection and then I feel tired all the time more so now than before taking Nplate.
—Posted by itp.goaway
29 Jun 2015
Nplate is the next to last option for me, I was hesitant on starting it, but didn't really have much choice. I get a shot weekly,and most weeks, it has kept my counts above 50K, only a few times has it dropped below. It even got me in a normal count range 4 times over the past almost 3 yrs. What I don't like is the leg pain, the feeling that my legs are getting an electric shock over and over, I also don't like the bone pain, joint pain and the muscle weakness as I've always been a very active physical type person. Depending upon the dosage, I'm not fit for much of anything at least 2 sometimes 3 days a week. I got the shot today, my counts were 45K. Within a couple of hours, I started with the leg pain and now the electric shock feeling. Think it's going be one of the bad weeks.
—Posted by Sunshine girl
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About Romiplostim
FDA Approves First Bone Marrow Stimulator to Treat Immune-Related Low Platelet Counts
The U.S. Food and Drug Administration today approved Nplate (romiplostim), the first product that directly stimulates the bone marrow to produce needed platelets in patients with a rare blood disorder that can lead to serious bleeding.
The condition, which usually develops in adults, is known as chronic immune thrombocytopenic purpura (ITP), a disease that results in a low number of platelets, the blood components that help with clotting. In patients with chronic ITP, the immune system is believed to destroy platelets and the patient's bone marrow is often unable to compensate for this loss.
"This product is important in that it offers a new approach to the treatment of patients with an uncommon blood disorder who are often very ill," said Janet Woodcock, M.D., director, Center for Drug Evaluation and Research, FDA. The estimated 140,000 people with chronic ITP are prone to bruising and at risk for life-threatening bleeding. Current medical treatment includes corticosteroids and immunoglobulin. Surgery to remove the spleen, a procedure known as a splenectomy, may help some patients. Nplate is approved only for patients with chronic ITP who do not respond sufficiently to current treatments.
FDA based its approval on two randomized clinical trials of about 125 patients who had received at least one prior ITP treatment. One study enrolled patients who still had their spleen, the other enrolled patients who did not. During six months of treatment, patients who received Nplate had significantly higher platelet counts and maintained those higher counts compared to those who did not receive the drug. The response to Nplate was higher in those patients who still had their spleen than in those patients who had undergone a splenectomy. In those patients who did not receive Nplate, only one experienced a sustained increase in platelet counts.
Safety concerns with Nplate include fibrous deposits in the bone marrow and the possibility that once Nplate is stopped, platelet counts could drop below what they were before beginning treatment.
Additional risks include blood clots due to excessive increases in platelets and, if Nplate were given to patients with an abnormal blood condition known as myelodysplasia, a risk for a form of blood cancer known as acute leukemia. Myelodysplasia, which is associated with low platelet counts, predisposes some patients to leukemia. In a study of 44 patients who had myelodysplasia and received Nplate, four patients developed leukemia. Further clinical trials in patients with predisposing conditions for leukemia will be needed to determine whether the development of leukemia may relate to the use of Nplate.
Nplate is approved only for use among patients with chronic ITP.A Risk Evaluation and Mitigation Strategy (REMS) has been developed to address the risks of Nplate therapy. Under the Food and Drug Administration Amendments Act of 2007, FDA has determined that a REMS is necessary for the benefits of Nplate to outweigh the risks of the product. The REMS will include a Medication Guide for patients and requires that all prescribers and patients enroll in a special program to track the long term safety of Nplate therapy.
Nplate is manufactured by Amgen, Inc. of Thousand Oaks, Calif.
Source: Wikipedia
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